Shiv Pillai, MD, PhD

Professor of Medicine and Health Sciences & Technology (HST) at Harvard Medical School

Program Director of the NIH-funded Autoimmune Center of Excellence at Massachusetts General Hospital

Director of the Harvard Immunology PhD and Master in Medical Sciences programs

Dr. Shiv Pillai is a world leader in the study of fundamental B-cell immunology. His work has contributed to breakthroughs in understanding the pathogenic mechanisms underlying an autoimmune fibrotic disorder, IgG4-related disease, with ongoing investigations involving the study of systemic sclerosis and common variable immunodeficiency (CVID). These findings have generated several clinical trials targeting the activated lymphocytes responsible for chronic inflammation and fibrosis in patients with these autoimmune disorders. Pillai is also interested in the role of DNA methylation in lymphocyte biology and the relevance of DNA methylation to memory, autoimmunity, and chronic lymphocytic leukemia.

Dr. Pillai is the author of a monograph “Lymphocyte Development” and co-author with Abul Abbas and Andrew Lichtman of two widely used textbooks of immunology. He is the course director of immunology courses at Harvard Medical School and Harvard College and for the Federation of Clinical Immunology Societies. Dr. Pillai has been the recipient of a number of teaching awards at Harvard, including the Irving M. London Award for Teaching and the Thomas McMahon Mentoring Award, and he has been included on The Harvard Crimson’s list of Professors of the Year.

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